bannerhome
 
 

News
Center

PDS0203 prioritized for clinical development by PDS Biotech and Farmacore after successful meeting with Brazilian Drug Regulatory Agency

FLORHAM PARK, N.J., Nov. 10, 2020 (GLOBE NEWSWIRE) -- PDS Biotechnology Corporation (Nasdaq: PDSB), a clinical-stage immunotherapy company developing novel cancer therapies and infectious disease vaccines based on the Company’s proprietary Versamune® T-cell activating technology, today announced progress on its co-development program with Farmacore Biotechnology for a Versamune®-based vaccine aimed at preventing COVID-19 infection.

Based on promising and robust preclinical data with PDS0203, and in the interest of rapid development, PDS Biotech and Farmacore have jointly prioritized advancement of PDS0203 to human clinical trials. PDS Biotech had previously announced the parallel development of two Versamune®-based COVID-19 vaccines PDS0203 and PDS0204 each containing different SARS-CoV-2 proteins. The decision to jointly develop PDS0203 was made with the support of the Agência Nacional de Vigilância Sanitária (ANVISA) following a successful pre-investigational new drug meeting on November 06, 2020. ANVISA and Farmacore reviewed the PDS0203 data and agreed on the path forward for official submission of a final data package and the phase 1/2 human clinical trial protocol. Farmacore is in discussions with specific agencies of the government to extend the preclinical funding to cover the upcoming human clinical trial anticipated to begin during the first half of 2021.

As previously disclosed, PDS Biotech has generated robust preclinical data demonstrating that PDS0203 elicits a 30-45 fold increase in the induction of highly active and potent virus-specific T-cells within 14 days of treatment compared to the vaccine without Versamune®. Importantly, the study also demonstrated induction of the long-lasting virus-specific memory T-cells necessary for longer term protection. The vaccine has also demonstrated strong and long-lasting induction of neutralizing antibodies. The PDS0203 subunit vaccine is based on recombinant proteins and does not require the use of inactivated viruses, traditional adjuvants, DNA or RNA to induce robust protective immune responses.

“PDS0203 may present strong potential to provide the breadth and level of immune responses necessary for a safe and effective vaccine with long-term protection against COVID-19," said Dr. Greg Conn, Chief Scientific Officer of PDS Biotechnology.

“PDS Biotech and Farmacore are now one step closer to advancing our Versamune®-based COVID-19 vaccine into the clinic,” said Dr. Frank Bedu-Addo, Chief Executive Officer of PDS Biotech. “The preclinical results of PDS0203 demonstrate its potential to induce a robust and broad immune response. We look forward to evaluating our next-generation vaccine in planned human clinical trials in partnership with Farmacore and to advance our understanding of the potential of novel Versamune®-based vaccines like PDS0203 to provide long-term protection against infection with viruses such as SARS-CoV-2.”

“In this global pandemic, it is incumbent upon the scientific community to be flexible and to ensure we are prioritizing the vaccine with the most clinical potential and that we can progress most quickly,” said Helena Faccioli, CEO of Farmacore. “We are excited to continue advancing the partnership with PDS Biotech, and we are thrilled to have the support of ANVISA to provide the opportunity to develop a treatment in Brazil in the fight against this pandemic.”

The companies plan to utilize multiple research and development sites in the United States and Brazil to progress preclinical and clinical development PDS0203.  Farmacore will lead the regulatory and clinical trial efforts in Brazil while PDS Biotech will continue to contribute scientific expertise and operational support.

About PDS Biotechnology

PDS Biotech is a clinical-stage immunotherapy company with a growing pipeline of cancer immunotherapies and infectious disease vaccines based on the Company’s proprietary Versamune® T-cell activating technology platform. Versamune® effectively delivers disease-specific antigens for in vivo uptake and processing, while also activating the critical type 1 interferon immunological pathway, resulting in production of potent disease-specific killer T-cells as well as neutralizing antibodies. PDS Biotech has engineered multiple therapies, based on combinations of Versamune® and disease-specific antigens, designed to train the immune system to better recognize disease cells and effectively attack and destroy them. To learn more, please visit www.pdsbiotech.com or follow us on Twitter at @PDSBiotech.

About Farmacore

Farmacore is a biotechnology company, founded in 2005 as a startup, focusing on R&D of innovative immunobiological products for use in the human and veterinary health sectors. It is a technology-based company that conducts research and development of biotechnological products and processes for the human and veterinary sectors. It develops innovative biotechnological and immunobiological products and adds value to them in all stages of development, from project design to biomolecule production www.farmacore.com.br.

About PDS0203

PDS0203 is an investigational vaccine designed for the prevention of COVID-19 being jointly developed by PDS Biotech and Farmacore. PDS0203 combines the utility of PDS Biotech’s Versamune® platform with a recombinant native Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) protein recognizable by our immune system (antigen). The Versamune® platform, due to its unique ability to induce both antibody and T-cell responses is being utilized to develop a next generation vaccine that may more effectively prevent COVID-19.

Forward Looking Statements

This communication contains forward-looking statements (including within the meaning of Section 21E of the United States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended) concerning PDS Biotechnology Corporation (the “Company”) and other matters. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the Company’s management, as well as assumptions made by, and information currently available to, management. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” “forecast.” “guidance”, “outlook” and other similar expressions among others. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: the Company’s ability to protect its intellectual property rights; the Company’s anticipated capital requirements, including the Company’s anticipated cash runway and the Company’s current expectations regarding its plans for future equity financings; the Company’s dependence on additional financing to fund its operations and complete the development and commercialization of its product candidates, and the risks that raising such additional capital may restrict the Company’s operations or require the Company to relinquish rights to the Company’s technologies or product candidates; the Company’s limited operating history in the Company’s current line of business, which makes it difficult to evaluate the Company’s prospects, the Company’s business plan or the likelihood of the Company’s successful implementation of such business plan; the timing for the Company or its partners to initiate the planned clinical trials for its lead asset PDS0101; the future success of such trials; the successful implementation of the Company’s research and development programs and collaborations, including any collaboration studies concerning PDS0101 and the Company’s interpretation of the results and findings of such programs and collaborations and whether such results are sufficient to support the future success of the Company’s product candidates; the acceptance by the market of the Company’s product candidates, if approved; the timing of and the Company’s ability to obtain and maintain U.S. Food and Drug Administration or other regulatory authority approval of, or other action with respect to, the Company’s product candidates; and other factors, including legislative, regulatory, political and economic developments not within the Company’s control, including unforeseen circumstances or other disruptions to normal business operations arising from or related to COVID-19. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in the Company’s annual and periodic reports filed with the SEC. The forward-looking statements are made only as of the date of this press release and, except as required by applicable law, the Company undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.

Media & Investor Relations Contact:

Deanne Randolph
PDS Biotech
Phone: +1 (908) 517-3613
Email: drandolph@pdsbiotech.com

Jacob Goldberger
CG Capital
Phone: +1 (404) 736-3841
Email: jacob@cg.capital


Receive Email Alerts

Join our mailing list to receive the latest news and updates from our team.

Sign up

pdf

This website use cookies to facilitate the use of the website, improve its performance and security, personalize the proposed content.

26.296MBMemory Usage337msRequest Duration
Joomla! Version5.2.4
PHP Version8.3.23
Identityguest
Response200
Templateg5_hydrogen
Database
Server
mysql
Version
10.11.13-MariaDB
Collation
utf8mb3_general_ci
Conn Collation
utf8mb4_general_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
[]
$_SERVER
array:54 [ "USER" => "new-pdsbiotech.com_0kvagq3svpga" "HOME" => "/var/www/vhosts/pdsbiotech.com...
session
array:3 [ "counter" => 1 "timer" => array:3 [ "start" => 1753519754 "last" => 1753519754...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:21 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
  • afterLoad (3.4MB) (23.78ms)
  • afterInitialise (8.05MB) (69.11ms)
  • afterRoute (3.33MB) (35.66ms)
  • beforeRenderComponent com_content (31.92KB) (814μs)
  • Before Access::preloadComponents (all components) (710.33KB) (6.64ms)
  • After Access::preloadComponents (all components) (136.78KB) (647μs)
  • Before Access::preloadPermissions (com_content) (1.85KB) (13μs)
  • After Access::preloadPermissions (com_content) (457.6KB) (1.19ms)
  • Before Access::getAssetRules (id:8 name:com_content) (329.89KB) (3.01ms)
  • After Access::getAssetRules (id:8 name:com_content) (24.93KB) (285μs)
  • Before Access::getAssetRules (id:1 name:root.1) (1.32MB) (15.08ms)
  • After Access::getAssetRules (id:1 name:root.1) (6.32KB) (22μs)
  • afterRenderComponent com_content (1.7MB) (24.74ms)
  • afterDispatch (21.82KB) (1.06ms)
  • beforeRenderRawModule mod_finder (Search) (3.99MB) (41.6ms)
  • afterRenderRawModule mod_finder (Search) (554.34KB) (6.96ms)
  • beforeRenderModule mod_finder (Search) (704B) (6μs)
  • afterRenderModule mod_finder (Search) (19.73KB) (828μs)
  • beforeRenderRawModule mod_ebstickycookienotice (Cookie Notice) (896.33KB) (86.78ms)
  • afterRenderRawModule mod_ebstickycookienotice (Cookie Notice) (13.67KB) (986μs)
  • beforeRenderModule mod_ebstickycookienotice (Cookie Notice) (736B) (6μs)
  • afterRenderModule mod_ebstickycookienotice (Cookie Notice) (5.41KB) (372μs)
  • afterRender (845.25KB) (17ms)
  • 1 x beforeRenderRawModule mod_ebstickycookienotice (Cookie Notice) (896.33KB) (25.73%)
    86.78ms
    1 x afterInitialise (8.05MB) (20.49%)
    69.11ms
    1 x beforeRenderRawModule mod_finder (Search) (3.99MB) (12.34%)
    41.60ms
    1 x afterRoute (3.33MB) (10.57%)
    35.66ms
    1 x afterRenderComponent com_content (1.7MB) (7.34%)
    24.74ms
    1 x afterLoad (3.4MB) (7.05%)
    23.78ms
    1 x afterRender (845.25KB) (5.04%)
    17.00ms
    1 x Before Access::getAssetRules (id:1 name:root.1) (1.32MB) (4.47%)
    15.08ms
    1 x afterRenderRawModule mod_finder (Search) (554.34KB) (2.06%)
    6.96ms
    1 x Before Access::preloadComponents (all components) (710.33KB) (1.97%)
    6.64ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (329.89KB) (0.89%)
    3.01ms
    1 x After Access::preloadPermissions (com_content) (457.6KB) (0.35%)
    1.19ms
    1 x afterDispatch (21.82KB) (0.31%)
    1.06ms
    1 x afterRenderRawModule mod_ebstickycookienotice (Cookie Notice) (13.67KB) (0.29%)
    986μs
    1 x afterRenderModule mod_finder (Search) (19.73KB) (0.25%)
    828μs
    1 x beforeRenderComponent com_content (31.92KB) (0.24%)
    814μs
    1 x After Access::preloadComponents (all components) (136.78KB) (0.19%)
    647μs
    1 x afterRenderModule mod_ebstickycookienotice (Cookie Notice) (5.41KB) (0.11%)
    372μs
    1 x After Access::getAssetRules (id:8 name:com_content) (24.93KB) (0.08%)
    285μs
    1 x After Access::getAssetRules (id:1 name:root.1) (6.32KB) (0.01%)
    22μs
    1 x Before Access::preloadPermissions (com_content) (1.85KB) (0%)
    13μs
    1 x beforeRenderModule mod_finder (Search) (704B) (0%)
    6μs
    1 x beforeRenderModule mod_ebstickycookienotice (Cookie Notice) (736B) (0%)
    6μs
35 statements were executed, 5 of which were duplicates, 30 unique6.17ms161.84KB
  • SELECT @@SESSION.sql_mode;39μs968B/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:308Copy
  • SELECT `data` FROM `sm_session` WHERE `session_id` = ?74μs1008BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:250Copy
  • SELECT `session_id` FROM `sm_session` WHERE `session_id` = :session_id LIMIT 152μs1.3KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `sm_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)178μs944BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `id`,`rules` FROM `sm_viewlevels`63μs976B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `sm_usergroups` AS `a` LEFT JOIN `sm_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest89μs1.33KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `params` FROM `sm_extensions` WHERE `type` = 'plugin' AND `folder` = 'system' AND `element` = 'admintools'99μs536B/plugins/system/admintools/src/Utility/RescueUrl.php:324Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `sm_categories` AS `s` INNER JOIN `sm_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`276μs4.14KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT s.id, s.template, s.home, s.title AS long_title, s.params FROM sm_template_styles AS s WHERE s.client_id = 0 AND s.template = 'g5_hydrogen' ORDER BY s.id107μs1.44KB/libraries/gantry5/src/classes/Gantry/Joomla/StyleHelper.php:69Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `sm_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44,:preparedArray45,:preparedArray46,:preparedArray47,:preparedArray48)385μs7.81KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `sm_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 0589μs49.48KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `sm_assets`293μs1.39KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:587Copy
  • SELECT * FROM `sm_assets` WHERE `name` = 'com_content.article.454'67μs912B/libraries/src/Table/Table.php:780Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `sm_content` AS `a` INNER JOIN `sm_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `sm_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `sm_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `sm_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `sm_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray1,:preparedArray2)237μs22.17KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `sm_categories` AS `s` INNER JOIN `sm_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`261μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `sm_contentitem_tag_map` AS `m` INNER JOIN `sm_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)149μs3.97KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT r.* FROM sm_rereplacer AS r WHERE r.published = 1 AND (r.area = 'articles') ORDER BY r.ordering, r.id93μs2.73KB/plugins/system/rereplacer/src/Items.php:95Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `sm_categories` AS `s` INNER JOIN `sm_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`256μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM sm_fields AS a LEFT JOIN `sm_languages` AS l ON l.lang_code = a.language LEFT JOIN sm_users AS uc ON uc.id=a.checked_out LEFT JOIN sm_viewlevels AS ag ON ag.id = a.access LEFT JOIN sm_users AS ua ON ua.id = a.created_user_id LEFT JOIN sm_fields_groups AS g ON g.id = a.group_id LEFT JOIN `sm_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC493μs4.81KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:164Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `sm_categories` AS `s` INNER JOIN `sm_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`276μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT r.* FROM sm_rereplacer AS r WHERE r.published = 1 AND (r.area = 'component') ORDER BY r.ordering, r.id94μs1.48KB/plugins/system/rereplacer/src/Items.php:95Copy
  • SELECT `a`.`menutype`,`a`.`title` FROM `sm_menu_types` AS `a` WHERE `a`.`client_id` = 065μs608B/libraries/gantry5/src/classes/Gantry/Framework/Menu.php:138Copy
  • SELECT m.id, m.alias, m.path AS route, m.level, m.parent_id FROM sm_menu AS m WHERE m.menutype = 'mainmenu' AND m.parent_id > 0 AND m.client_id = 0 AND m.published >= 0 ORDER BY m.lft561μs2.23KB/libraries/gantry5/src/classes/Gantry/Framework/Menu.php:791Copy
  • SELECT `name`,`element` FROM `sm_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1224μs656B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `sm_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)81μs520B/administrator/components/com_finder/src/Indexer/Taxonomy.php:325Copy
  • SELECT * FROM `sm_schemaorg` WHERE `itemId` = :itemId AND `context` = :context78μs1.55KBParams/plugins/system/schemaorg/src/Extension/Schemaorg.php:403Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `sm_content` AS `a` INNER JOIN `sm_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `sm_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `sm_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `sm_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `sm_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray1,:preparedArray2)237μs22.17KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `sm_scheduler_tasks` AS `a` WHERE `a`.`state` = 192μs1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517Copy
  • SELECT r.* FROM sm_rereplacer AS r WHERE r.published = 1 AND (r.area = 'head') ORDER BY r.ordering, r.id96μs1.48KB/plugins/system/rereplacer/src/Items.php:95Copy
  • SELECT r.* FROM sm_rereplacer AS r WHERE r.published = 1 AND (r.area = 'body') ORDER BY r.ordering, r.id79μs1.5KB/plugins/system/rereplacer/src/Items.php:95Copy
  • SELECT r.* FROM sm_rereplacer AS r WHERE r.published = 1 AND (r.area = 'everywhere') ORDER BY r.ordering, r.id94μs1.48KB/plugins/system/rereplacer/src/Items.php:95Copy
  • SELECT `alias` FROM `sm_content` WHERE `id` = :id61μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `sm_categories` AS `s` INNER JOIN `sm_categories` AS `c` ON (`s`.`lft` <= `c`.`lft` AND `c`.`lft` < `s`.`rgt`) OR (`c`.`lft` < `s`.`lft` AND `s`.`rgt` < `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`125μs6.37KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `session_id` FROM `sm_session` WHERE `session_id` = ?63μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:277Copy
  • UPDATE `sm_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?148μs592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:301Copy
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content
  • warningassets - No asset found for com_content.article.454, falling back to com_content