December 15, 2014: NetScientific Invests in Next Generation, Immunotherapeutics Company, PDS Biotechnology. NetScientific (AIM: NSCI), the biomedical and healthcare technology group, today announced it has made an investment in PDS Biotechnology Corporation (‘PDS’). Farad Azima, CEO, “This is an exceptional opportunity for NetScientific. As we stated in our recent results, we have been evaluating opportunities in the therapeutic space. PDS Biotechnology is at the forefront of cancer immunotherapies and by investing in the company, represents our entry into next generation therapeutics.”
PDS Biotechnology is a clinical stage Biopharmaceutical Company developing the next-generation of simpler, safer and more effective immunotherapies for cancer and other disease areas such as infectious disease.
To see how Versamune™ works, please click here.
Stimulating, and training the immune system to recognize and kill cancer cells has been demonstrated to be one of the most promising approaches to treating various types of cancer.
It is now well established that cancers can be classified by the type of unique protein “antigen” expressed by the particular cancer cells. PDS Biotechnology is focusing its initial product pipeline on a number of cancers which express a few well-characterized cancer antigens. For example, the company’s first cancer immunotherapy, PDS0101 treats cancers caused by infection with the human papillomavirus. Such cancers include cervical, oral, anal, vulvar and penile cancers, as well as intraepithelial neoplasia. . The PDS0101 product is currently in Phase I human clinical trials at multiple sites in the US.
Other debilitating cancers potentially addressable by PDS’s product technology include ovarian cancer, pancreatic cancer, melanoma, leukemia, and multiple myeloma.
PDS Biotechnology has developed a simple and synthetic nanoparticle platform vector known as Versamune®. This novel and superior nanotechnology platform is very effective in training the immune system to recognize and fight the particular disease (see video on how Versamune® works). To do so, the unique protein antigen from the particular cancer type is formulated and injected with Versamune®. In pre-clinical studies very effective and superior treatment of advanced aggressive cancers with low doses of the Versamune®-based products has been demonstrated. The preclinical and on-going clinical studies have also demonstrated that the Versamune®-based cancer immunotherapies are exceptionally safe and well tolerated. Versamune® is the first synthetic immunotherapy and immunotherapy vector to demonstrate potent disease killing T-cell responses without the need for the addition of immune activators known as adjuvants.
PDS Biotechnology is initially applying the Versamune® vector to the treatment of HPV related cancers such as cervical cancer, oral cancer and cervical intraepithelial neoplasia (pre-cervical cancer). PDS’s lead HPV cancer immunotherapy product, PDS0101 is currently in phase 1 human clinical trials at multiple clinics within the US.
In 2012, PDS signed a licensing agreement with a global pharmaceutical company, Merck KGaA, granting it a license to utilize PDS Biotechnology’s patented Versamune® technology in the development of novel cancer immunotherapies.